Myeloproliferative MPL gene cancer diagnostics
Purpose of the test
The myeloproliferative leukemia gene (MPL) encodes a thrombopoietin receptor protein (CD110). Somatic mutations at p.W515L, p.W515K are associated m.in with severe anaemia and are detected in patients with essential thrombocythemia (ET) and primary myelofibrosis (MF). The mutation rate is 0% in PV (polycythemia vera), 1% in ET and 5-7% in MF.
Indications for performing the test
Diagnosis of myeloproliferative tumors with the absence of mutations in the JAK2 gene. JAK2.
Frequency of MPL mutations in exon 10:
- essential thrombocythemia – about 1%
- myelofibrosis – 5-8%
For more information:
Essential thrombocythemia
Myelofibrosis
The test material should be collected using the sent PAXgene DNA blood CE IVD whole blood kit.
The collected material should be sent to the laboratory.
THE MATERIAL CAN BE STORED AT ROOM TEMPERATURE WITHOUT AFFECTING ITS QUALITY FOR UP TO 14 DAYS.
Delivery of the set and collection of the downloaded material is FREE
180.00 zł
Still in doubt? Any questions?
We encourage you to contact us to resolve any doubts!
Napisz do nas, korzystając w formularza lub umów bezpłatną wstępną konsultacje
